Pediatric trauma mortality in India and the United States: A comparison and risk-adjusted analysis.

BACKGROUND: There is a paucity of research comparing pediatric risk-adjusted trauma mortality between high-income and low- and middle-income countries. This limits identification of populations and injury patterns for targeted interventions. We aim to compare independent predictors of pediatric trauma mortality between India and the United States (US). METHODS: A retrospective cohort study was conducted for pediatric patients (age <18 years) in India's Towards Improved Trauma Care Outcomes (TITCO) project database and the US National Trauma Data Bank (NTDB) from 2013 to 2015. Demographic, injury, physiologic, anatomic and outcome data were analyzed. Multivariable regressions were used to determine independent predictors of mortality. RESULTS: 126,678 pediatric trauma patients were included (India 3,373; US 123,305). Pediatric patients in India were on average significantly younger, with a higher median injury severity score (ISS), had lower systolic blood pressure, and suffered a higher case fatality rate (13.0% vs. 1.0%). When controlling for demographic, mechanism, physiologic, and anatomic injury characteristics, sustaining an injury in India was the strongest predictor of mortality (OR 22.70, 95% CI 18.70-27.56). On subgroup analysis, the highest relative odds of mortality in India was seen in children with lower injury and physiologic severity. CONCLUSIONS: Risk-adjusted pediatric trauma-related mortality is significantly higher in India compared to the US. The comparative odds of mortality are highest among children with lower injury and physiologic severity. This suggests that low-cost targeted interventions focused on standard timely trauma care, protocols, training and early imaging could improve pediatric injury mortality in India. TYPE OF STUDY: Retrospective Prognosis Study LEVEL OF EVIDENCE: II.

Delayed Presentation of Meconium Ileus in an Infant With Cystic Fibrosis.

Although infants with meconium ileus usually present with apparent symptoms shortly after birth, the diagnosis of meconium ileus and cystic fibrosis (CF) may be delayed, awaiting newborn screening (NBS) results. We present the case of an 11-day-old term girl with delayed passage of meconium at 48 hours who had 2 subsequent small meconium stools over the following week. There was a normal feeding history and no signs of abdominal distension or distress. She then presented with an acute abdomen, decompensated shock, bowel perforation, and peritonitis, requiring multiple intestinal surgeries. Her NBS for CF was positive, and CF was ultimately confirmed with mutation analysis. Her course was complicated by prolonged parenteral feedings and mechanical ventilation via tracheostomy. The infant was managed with soy oil, medium chain triglycerides, olive oil, fish oil lipids and experienced only transaminitis without cholestasis and no chronic liver sequelae, with subsequent normalization of her transaminases without treatment. Because her only symptom was decreased stool output and NBS results were unavailable, the CF diagnosis was delayed until she presented in extremis. Delayed meconium passage and decreased stool output during the first week of life should lead to suspicion and additional evaluation for CF while awaiting NBS results. Careful monitoring is indicated to prevent serious, life-threatening complications. The use of soy oil, medium chain triglycerides, olive oil, fish oil lipids for infants requiring prolonged parenteral nutrition may also be considered proactively to prevent cholestasis, particularly for high risk groups.

Management of Isolated Skull Fractures in Pediatric Patients: A Systematic Review.

OBJECTIVES: Isolated skull fractures (ISFs) in children are one of the most common emergency department injuries. Recent studies suggest these children may be safely discharged following ED evaluation with little risk of delayed neurological compromise. The aim of this study was to propose an evidence-based protocol for the management of ISF in children in an effort to reduce medically unnecessary hospital admissions. METHODS: Using PubMed and The Cochrane Library databases, a literature search using the search terms (pediatric OR child) AND skull fracture AND (isolated OR linear) was performed. Three hundred forty-three abstracts were identified and screened based on the inclusion criteria: (1) linear, nondepressed ISF; (2) no evidence of intracranial injury; (3) age 18 years or younger; and (4) data on patient outcomes and management. Data including age, Glasgow Coma Scale score on arrival, repeat imaging, admission rates, need for neurosurgical intervention, and patient outcome were collected. Two authors reviewed each study for data extraction and quality assessment. RESULTS: Fourteen articles met the eligibility criteria. Data including admission rates, outcomes, and necessity of neurosurgical intervention were analyzed. Admission rates ranged from 56.8% to 100%; however, only 8 of more than 5000 patients developed new imaging findings after admission, all of which were nonsurgical. Only 1 patient required neurosurgical intervention for a finding evident upon initial evaluation. CONCLUSIONS: Pediatric ISF patients with a presenting Glasgow Coma Scale score of 15 who are neurologically intact and tolerating feeds without concern for nonaccidental trauma or an unstable social environment can safely be discharged following ED evaluation to a responsible caregiver.

The certifying examination of the american board of surgery: the effect of improving communication and professional competency: twenty-year results.

PURPOSE: In 1985, a small research group identified variables affecting applicant success on the oral Certifying Examination (CE) of the American Board of Surgery (ABS). This led to the design of an oral examination course first taught in 1991. The success of and need for this program led to its continuation. The results from the first 10 years were presented at the 2001 Association of Program Directors in Surgery annual meeting.(1) We now report the outcomes for the course of the second 10 years as measured by success on the CE. METHODS: Thirty-six courses were held over 20 years. There were 57 invited faculty from 27 general surgery programs throughout the United States and Canada. The participant-to-faculty ratio ranged from 16:7 to 5:1 in the newer 3-day format (2007). Courses were offered at sites that replicated the actual examination setting. Each course included (1) pretest and posttest examinations, (2) analysis of case presentation skills, (3) measurement of communication apprehension, (4) 1:1 faculty feedback, (5) small-group practice sessions, (6) individual videotaping, (7) didactic review of specific behaviors on examinations, (8) a debrief session with two faculty members, and (9) a written evaluative summary that included an improvement strategy. RESULTS: There were 36 courses with 326 participants (30-54 years). Follow-up data are available for 225 participants. Trends were analyzed between 1991-2001 and 2002-2011. As resident performance on the CE increased in importance, applicant profiles changed from those who had previously failed (1991-2001) to residents identified by program directors as needing assistance (52%). Since 2002, most course participants (69%) who had failed the CE had completed at least 1 other review course. Participants reported more significant stressors (2002-2011) 9%, but communication apprehension remained the same. As a result, individual counseling for anger and family stressors was integrated into the course. The perception of knowledge deficits was associated with those who enrolled in fellowship training and delayed their examination. The recent groups exhibited more professionalism and articulation issues related to performance. Five surgeons (2002-2011) were asked not to return to the course because of severe knowledge deficiencies or ethical/behavioral issues based on faculty evaluations. Although complete follow-up of all participants was not possible (only 225/326), the success rate among those providing follow-up was 97% for those who followed their remediation plan, giving 218/326, a worse-case pass rate of 67%. CONCLUSION: Communication and professionalism deficits are still common in those struggling with the CE, Early identification of those at risk of failing by program directors who are documenting the competencies may promote earlier interventions and thus lead to success. This program continues to be effective at identifying behaviors that interfere with success on the CE of the ABS.

Angiographic embolization is safe and effective therapy for blunt abdominal solid organ injury in children.

BACKGROUND: : Angiographic embolization (AE) is used to control hemorrhage in adult blunt liver, spleen, and kidney (ASO) injuries. Pediatric experience with AE for blunt ASO injuries is limited. We reviewed our use of AE to control bleeding pediatric blunt ASO injuries for efficacy and safety. METHODS: : A 5-year review (trauma registry and charts) of children (age < or = 16 years) who had AE for hemorrhage from blunt ASO injuries. Nonoperative management was attempted in all stable children with blunt ASO injuries. Children with ongoing hemorrhage underwent AE. The success of AE and complications were evaluated. Data were reviewed on injury type and grade, injury severity score, length of intensive care unit stay (LOS-ICU) and length of hospital stay (LOS), and complications. RESULTS: : One hundred twenty-seven patients with 149 blunt ASO injuries were identified (72 spleen, 51 liver, and 26 renal). Two children had immediate splenectomies. Seven children underwent AE: two spleen (grades IV and V), two liver (grades III and IV), and three grade IV renal injuries. Three children received blood before embolization. Mean age and injury severity score were 12.3 years +/- 3.7 years and 22.4 +/- 10.0,respecyively. Mean intensive care unit stay was 4.8 days +/- 5.5 days with a mean length of hospital stay of 12.8 days +/- 5.5 days. Embolization was successful in all children; there were no procedure-related complications. Four minor complications occurred; two pleural effusions and two patients with transient hypertension. A nephroblastoma was later found in one renal injury requiring nephrectomy. CONCLUSIONS: : AE is a safe and an effective technique for controlling hemorrhage from blunt ASO injuries in select pediatric patients.

Fait accompli: suicide in a rural trauma setting.

OBJECTIVES: Over the past 20 years, the rate of suicide in rural communities has surpassed those of urban areas. The number of rural trauma patients who attempt suicide, are treated and survive at a trauma center, but ultimately reattempt suicide and succeed (suicide recidivists) is unknown. We have characterized all adult suicide deaths seen at a rural Level I trauma center and identified predictors of a successful suicide. We hypothesized that rural adult trauma patients exhibit a high rate of suicide recidivism. METHODS: This is a 10-year single institutional retrospective cohort analysis. All adult admissions to our rural, Level I trauma center from 1997 to 2007 (n = 9147) were cross referenced with a Vermont Medical Examiner database containing information regarding all suicide deaths in the state of Vermont from 2002 to 2007 (n = 502); the 32 matches are the subject of this research. RESULTS: One half (16 of 32) of patients who died by suicide had a previous admission to the trauma service. Index hospital length of stay (LOS, p < 0.02), intensive care unit-LOS (p < 0.01), and ventilator days (p < 0.01) were significantly different between trauma patients who subsequently died by suicide and general trauma patients. The average delay from initial presentation to suicide death was 2.8 years. Eighteen of 28 (64%) of suicide attempters had previous trauma admissions for self-inflicted injury (p < 0.001). Eighteen of 156 (12%) of previous self-inflicted injury admissions resulted in future suicide attempt (NNT = 9). A logistic regression model identified the following variables present at the index hospitalization as significant predictors of future suicide: self-inflicted injury, penetrating mechanism of injury, longer hospital LOS, younger age, and female gender. CONCLUSION: The overwhelming majority (94%) of suicide deaths in our rural state were never seen by the trauma center, and only 1.1% were recidivists. Previous admissions for self-inflicted injuries or penetrating injuries were significant predictors of future suicide attempt and should trigger select interventions. Other factors that can to lead a suicidal tendency include a previous mental health history (depression), poly-substance abuse, and chronic pain history. In our small sample, suicidal tendencies could persist for a prolonged period of time.

Implementation of resident work hour restrictions is associated with a reduction in mortality and provider-related complications on the surgical service: a concurrent analysis of 14,610 patients.

OBJECTIVE: To determine the effect of implementation of work hour restrictions on the rates of morbidity, mortality, and provider-related complications in surgical patients and to determine the incremental personnel costs associated with implementation. SUMMARY BACKGROUND DATA: In 2003, the Accreditation Council for Graduate Medical Education enacted resident work hour restrictions (RWHR) to improve patient safety by decreasing errors attributed to resident fatigue. There are no quantitative data on surgical patients to validate whether this objective has been achieved and, if so, at what cost. METHODS: Retrospective observational cohort analysis of data gathered concurrently with patient care for 30 days after admission or surgical intervention before implementation (prerestriction: July 2001-June 2003) and after (postrestriction: July 2005-June 2007). MAIN OUTCOME MEASURES: mortality, surgical complications, percentage of complications judged to be provider-related, and incremental personnel costs (salary and fringe of providers). RESULTS: A total of 14,610 patients were admitted during the 2 periods. Compared with the prerestriction period, there was a significant reduction in the percentage of complications attributed to providers (pre: 48.3%; post: 38.6%, P < 0.001) and a significant reduction in mortality rate (pre: 1.9%; post: 1.1%, P = 0.002) in the postrestriction period. Postrestriction the clinical care hours provided by attending surgeons increased significantly and was associated with a 1250% increase in the RVU-82 billing modifier ("no qualified resident available") from 523 RVUs pre-RWHR to 6542 post-RWHR. There was an increase in annual personnel costs postrestriction of $1.466 million. CONCLUSIONS: Implementation of RWHR was associated with reduced provider-related complications and mortality suggesting improved patient safety. This was likely due to several factors including reduced resident fatigue and greater attending involvement in clinical care.

Blunt pancreatoduodenal injury: a multicenter study of the Research Consortium of New England Centers for Trauma (ReCONECT).

OBJECTIVES: To evaluate the safety of nonoperative management (NOM), to examine the diagnostic sensitivity of computed tomography (CT), and to identify missed diagnoses and related outcomes in patients with blunt pancreatoduodenal injury (BPDI). DESIGN: Retrospective multicenter study. SETTING: Eleven New England trauma centers (7 academic and 4 nonacademic). PATIENTS: Two hundred thirty patients (>15 years old) with BPDI admitted to the hospital during 11 years. Each BPDI was graded from 1 (lowest) to 5 (highest) according to the American Association for the Surgery of Trauma grading system. MAIN OUTCOME MEASURES: Success of NOM, sensitivity of CT, BPDI-related complications, length of hospital stay, and mortality. RESULTS: Ninety-seven patients (42.2%) with mostly grades 1 and 2 BPDI were selected for NOM: NOM failed in 10 (10.3%), 10 (10.3%) developed BPDI-related complications (3 in patients in whom NOM failed), and 7 (7.2%) died (none related to failure of NOM). The remaining 133 patients were operated on urgently: 34 (25.6%) developed BPDI-related complications and 20 (15.0%) died. The initial CT missed BPDI in 30 patients (13.0%); 4 of them (13.3%) died but not because of the BPDI. The mortality rate in patients without a missed diagnosis was 8.8% (P = .50). There was no correlation between time to diagnosis and length of hospital stay (Spearman r = 0.06; P = .43). The sensitivity of CT for BPDI was 75.7% (76% for pancreatic and 70% for duodenal injuries). CONCLUSIONS: The NOM of low-grade BPDI is safe despite occasional failures. Missed diagnosis of BPDI continues to occur despite advances in CT but does not seem to cause adverse outcomes in most patients.

Initial resection of potentially viable tissue is not optimal treatment for grades II-IV pancreatic injuries.

PURPOSE: This study was designed to ascertain the optimal therapy and diagnostics for children with pancreatic injury. METHODS: From January 1, 2001 to January 1, 2007, all children (newborn to 17 years) who presented to this Level I trauma center with demonstrated pancreatic injury were prospectively entered into the TRACS IV system and reviewed for injury type, diagnostics, therapy, demographics, and outcome. RESULTS: Fourteen children sustained grade II or higher pancreatic injury during this period. CT scan was performed for diagnosis in all cases. There were 11 boys and 3 girls, and mean age was 6.9 (range, 2-16) years. There were five grade II injuries, four grade III injuries, four grade IV injuries, and one grade V injury. All grade II injuries were treated successfully nonoperatively with observation. The nine grade III-IV injuries all underwent operative external drainage without pancreatectomy or stent placement. The single grade V injury died of multiple associated injuries after operative intervention. No pseudocysts developed in these children. All children have normal pancreatic function, and all except one have normal anatomy on follow-up scans. Early exploration and drainage directly reduces length of stay. CONCLUSION: Grade II pancreatic injuries do not require routine surgical exploration in children. Grade III and IV injuries in this series were treated with expeditious drainage of the pancreatic bed and did not require routine pancreatectomy or endoscopic stent [corrected] placement as some have recommended. Early drainage shortens hospital stay, and outcomes from this therapy are excellent. Pancreatic resection of exocrine defunctionalized segments of pancreas may be performed safely electively after acute injury if necessary, but anecdotal information from this series indicates that too may not be necessary. Grade V injuries often are accompanied by multiple other organ injuries and are associated with a significant mortality rate. A multi-institutional investigation is warranted to reassess optimal therapy for pancreatic injury in children.

Effects of differences in percent total body surface area estimation on fluid resuscitation of transferred burn patients.

We sought to analyze the effect that differences in estimation of burn size and burn resuscitation had on complications and death among our transferred burn patients, in comparison with outcomes for burn patients directly admitted to our rural Level 1 trauma center. A retrospective chart review was performed for all patients suffering thermal injuries who were treated at a rural Level I trauma center and regional burn center. Percent TBSA burn estimates at referring hospitals were compared to burn center estimates. The Parkland formula was used to calculate the difference between the theoretical and actual resuscitation volumes given prior to admission. Of 127 burn patients, 82 (65%) were transferred from outside hospitals. For small burns (<20% TBSA), the mean estimate difference between outside hospitals and the burn center was 4.3 +/- 6.9%. For large burns (> or =20% TBSA), the mean estimate difference was -4.9 +/- 9.1% (P < .0002). The mean difference in intravenous fluid administered prior to admission to the burn center and the Parkland formula guideline was an excess of 554 +/- 1099 ml for small burns and a deficit of -414 +/- 2081 ml for larger burns (P = .03, Wilcoxon's rank-sum test). Differences in burn estimation and deviation from the Parkland formula were not statistically significant for complication and death. In the rural, transferred burn patient, smaller burns tended to be overestimated and overresuscitated and larger burns tended to be underestimated and underresuscitated.

The safety and efficacy of spinal anesthesia for surgery in infants: the Vermont Infant Spinal Registry.

Studies with modest numbers of patients have suggested that spinal anesthesia in infants is associated with a very infrequent incidence of complications, such as hypoxemia, bradycardia, and postoperative apnea. Although spinal anesthesia would seem to be a logical alternative to general anesthesia for many surgical procedures, it remains an underutilized technique. Since 1978, clinical data concerning all infants undergoing spinal anesthesia at the University of Vermont have been prospectively recorded. In all, 1554 patients have been studied. Anesthesia was performed by anesthesia trainees and attending anesthesiologists. The success rate for LP was 97.4%. An adequate level of spinal anesthesia was achieved in 95.4% of cases. The average time required to induce spinal anesthesia was 10 min. Oxygen hemoglobin desaturation to <90% was observed in 10 patients. Bradycardia (heart rate <100 bpm) occurred in 24 patients (1.6%). This study confirms the infrequent incidence of complications associated with spinal anesthesia in infants. Spinal anesthesia can be performed safely, efficiently, and with the expectation of a high degree of success. Spinal anesthesia should be strongly considered as an alternative to general anesthesia for lower abdominal and lower extremity surgery in infants.

Use of vena cava filters in pediatric trauma patients: data from the National Trauma Data Bank.

BACKGROUND: Placement of vena cava filters (VCFs) in high-risk adult trauma patients is a well-described intervention for prophylaxis against pulmonary embolism (PE). Few data exist regarding the use of VCFs in pediatric trauma. METHODS: We performed a cross-sectional study using the National Trauma Data Bank of the American College of Surgeons. Patients 17 years old or younger were included. Data regarding demographics, injuries, hospitalization, survival, and treating institution were analyzed. The prevalence of deep vein thrombosis (DVT), PE, and VCF placement were calculated. Odds ratios (ORs) for predictors of VCF placement were determined using multivariate logistic regression. RESULTS: There were 116,357 pediatric patients in the National Trauma Data Bank. VCFs were placed in 214 (0.18%) patients. VCF patients had longer mean hospital (23.99 vs. 4.12 days) and intensive care unit stays (13.65 vs. 1.12 days) and more severe injuries (mean Injury Severity Score, 30.89 vs. 9.04) than those without VCFs. Sixty-five patients had DVT, and PE was diagnosed in 28 patients, representing 0.06% and 0.02% of the cohort, respectively. University-associated teaching hospitals placed 72.4% (95% confidence interval, 65.9-78.3%) of VCFs and Level I trauma centers placed 46.3% (95% confidence interval, 39.4-53.2%) of VCFs. In multivariate analysis, significant predictors of VCF use were DVT (OR, 33.13), spinal cord injury (OR, 15.28), probability of survival (OR, 10.52), severe femur fracture (OR, 3.39), increasing age (OR, 1.99), ISS (OR, 1.05), intensive care unit stay (OR, 1.04), and length of stay (OR, 1.02). Higher Glasgow Coma Scale score decreased the likelihood of VCF use (OR, 0.87). CONCLUSION: Placement of VCFs in pediatric trauma patients is uncommon and is associated with several characteristics of the patient, the injury, and the treating institution. Long-term VCF efficacy in pediatric trauma is not known, and application of VCFs in these patients requires further investigation.

Workload redistribution: a new approach to the 80-hour workweek.

BACKGROUND: The new Accreditation Council for Graduate Medical Education-mandated 80-hour resident work week has resulted in busy trauma services struggling to meet these strict guidelines, or face loss of accreditation. METHODS: Beginning in July 2003, our Level I trauma service began a policy of direct admission of isolated neurosurgical or orthopedic injuries to the specific subspecialty service after complete evaluation by the trauma service in the emergency department for associated injuries. Complications, missed injuries, delayed diagnoses, and admission rates were compared in two 6-month periods: PRE, before the policy change; and POST, after the new policy had been instituted. Resident work hours were likewise compared over the two time periods. RESULTS: Selected single-system injury admission to subspecialty services resulted in a 15% reduction in admissions to the trauma service. There were no significant differences in the overall complication rate, delayed diagnoses, or missed diagnoses between the PRE and POST time periods. Overall, there was a 9.7% reduction in resident work hours (p = 0.45; analysis of variance) between the PRE and POST periods, which allowed them, on average, to meet the Accreditation Council for Graduate Medical Education 80-hour workweek mandate. CONCLUSION: Direct admission of patients with isolated injuries to subspecialty services is safe and decreases the workload of residents on busy trauma services.

The diagnosis and management of children with blunt injury of the chest.

Thoracic trauma remains a major source of morbidity and mortality in injured children, and is second only to brain injuries as a cause of death. The presence of a chest injury increases an injured child's mortality by 20-fold. Greater than 80% of chest injuries in children are secondary to blunt trauma. The compliant chest wall in children makes pulmonary contusions and rib fractures the most common chest injuries in children. Injuries to the great vessels, esophagus, and diaphragm are rare. Failure to promptly diagnose and treat these injuries results in increased morbidity and mortality.